منابع مشابه
Hypertension and the risk of mild cognitive impairment.
OBJECTIVE To explore whether hypertension is associated with the risk of mild cognitive impairment (MCI), an intermediate stage of dementia, because there are conflicting data relating hypertension to the risk of Alzheimer disease. DESIGN AND SETTING Prospective community-based cohort study conducted in northern Manhattan. Multivariate proportional hazards regression analyses were used, relat...
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Objective Alzheimer's disease and vascular dementia are responsible for more than 80% of dementia cases. These two conditions share common risk factors including hypertension. Cerebral small vessel disease (CSVD) is strongly associated with both hypertension and cognitive impairment. In this review, we identify the pathophysiological changes in CSVD that are caused by hypertension and further e...
متن کاملHypertension & Cognitive Impairment Hypertension Induces Brain -Amyloid Accumulation, Cognitive Impairment, and Memory Deterioration Through Activation of Receptor for Advanced Glycation End Products in Brain Vasculature
Although epidemiological data associate hypertension with a strong predisposition to develop Alzheimer disease, no mechanistic explanation exists so far. We developed a model of hypertension, obtained by transverse aortic constriction, leading to alterations typical of Alzheimer disease, such as amyloid plaques, neuroinflammation, blood-brain barrier dysfunction, and cognitive impairment, shown...
متن کاملEvaluation of Relationship Between Depression and Cognitive Impairment in Elderly
Objectives: Depression and cognitive impairments are the most common problem among elderlypeople that both of them cause decreasing the quality of life and functionality and increasing mortality rate. The aim of this study is determination of relationship between depression and cognitive impairments. Methods & Materials: In these cross sectional study we use Geriatric Depression Scale (GDS) ...
متن کاملDiabetes and Cognitive Impairment
Dr. José A. Luchsinger is Associate Professor of Medicine and Epidemiology, Columbia University Medical Center, New York, NY. Dr. Christopher Ryan is Director, Human Research Protection Program, University of California San Francisco, San Francisco, CA. Dr. Lenore J. Launer is Senior Investigator and Chief, Neuroepidemiology Section, Laboratory of Epidemiology and Population Sciences, National ...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2017
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2017.03.99